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The gastrointestinal side effects commonly reported with oral berberine (including diarrhoea, constipation, and abdominal discomfort) are often cited as reasons to seek alternative delivery methods, but switching to an unproven transdermal product is not a scientifically justified solution

Never use plain sterile or tap water

Factor in brand credibility, weight, cost, and actual performance tests

At the same time, some employers who were part of the first wave of companies to cover the drugs are now narrowing the criteria people need to meet to qualify for coverage

STEP, Semaglutide Treatment Effect in People with Obesity