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Data sources Orforglipron ATTAIN-1 trial: Eli Lilly press release (August 2025) Tirzepatide SURMOUNT-1 trial: Eli Lilly published data Indirect comparison metaanalysis: Circulation (2024) GI adverse events metaanalyses: Endocrinology, Diabetes & Metabolism (2024) and Diabetes, Obesity and Metabolism (2023)

Data are presented as point estimates of hazard ratios (HRs) as the measure of centre, with error bars defining the 95% confidence intervals (CIs)

If you are taking a lower dosage than that and still feeling hungry, check in with your healthcare provider

Considering switching insurers in order to keep your prescription

Injection considerations: These drugs require self-injection, with varying frequency (daily vs