However, avoid sudden increases in exercise intensity or duration, which may trigger cramps
McCaffrey DF, Griffin BA, Almirall D, et al
These findings suggest that NMDA receptor antagonists may serve as adjunct therapies to enhance the efficacy and tolerability of dopaminergic treatments and combinations with other antagonists
For example, the first amino acid (Tyr1), forms several key interactions with the receptor - its backbone carbonyl forms a hydrogen bond with the side chain atoms of Arg300, while the side chain atoms form hydrogen bonds with Gln224 and hydrophobic interactions with Trp296 of the receptor (Figure 4, inset 2a)
People who regularly take metformin, proton pump inhibitors, and H2 blockers, or have gastrointestinal disease are also at increased risk