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Paul BD, Sbodio JI, Snyder SH (2018) Cysteine metabolism in neuronal redox homeostasis

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This effect is supported by increased glucose flux through the noncanonical PPP, resulting in higher NADPH production, which promotes lysosomal maturation and maintains intracellular redox balance, thereby facilitating more efficient clearance of ACs [92] (Fig

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The magnitude of difference was particularly notable for weight loss, suggesting that GIP receptor activation contributes meaningfully to metabolic improvements beyond GLP-1 effects alone