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These medications thin and sensitize the skin barrier, and adding a chemical exfoliant creates a risk of severe irritation, prolonged healing, and scarring

De Hert M, Dekker JM, Wood D, Kahl KG, Holt RIG, Mller HJ

If this is all a little complex, just remember this: glutathione plays a role in making toxins water soluble so you can get them out of your body

They are metabolised and eliminated through different pathways: semaglutide is broken down by proteolytic enzymes (similar to endogenous proteins) and does not rely on cytochrome P450 liver enzymes, whilst topiramate is partially metabolised hepatically but largely excreted unchanged in urine

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