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Standard dose escalation timeline The FDA-approved tirzepatide dose schedule follows a structured escalation pattern: Weeks 1 through 4: 2.5 mg once weekly (starting dose) Weeks 5 through 8: 5 mg once weekly Weeks 9 through 12: 7.5 mg once weekly Weeks 13 through 16: 10 mg once weekly Weeks 17 through 20: 12.5 mg once weekly (if needed) Week 21 onward: 15 mg once weekly (maximum dose) You reach 7.5 mg at approximately week 9

TRIUMPH-1 extended this picture significantly: TRIUMPH-4 trajectory (68 weeks): Week 68: 28.7% weight loss Note: Intermediate timepoint data (weeks 2448) was not reported in the December 2025 topline release

The Results In this study, 3,346 people with obesity, meaning a BMI over 30, but without diabetes started GLP-1 therapy and were compared to 8,343 similar people not using GLP-1 drugs

Our conservative titration approach is deliberate

Realistic Expectations: Month-by-Month Weight Loss Patterns During weeks 1-4, many patients report reduced hunger and food cravings but modest weight loss of 2-4 pounds total as their bodies begin responding to the medication