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Regular hormone panels, semen analyses, and symptom logs let clinicians adjust doses or swap agents to target true synergy rather than additive side effects

In addition to the findings with ASMase knockout mice, which models the lysosomal storage disorder NiemannPick type A disease, inhibition of glucocerebrosidase in hepatocytes by conduritol -epoxide, a cellular model of Gaucher disease that exhibits lysosomal cholesterol accumulation sensitizes to APAP-induced cell death (Baulies et al., 2015)

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