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The cells treated with L-GSH may also have synthesized additional endogenous GSH since the cytokines IL-6 and TGF- are known to decrease GSH synthesis and these cytokines were found to be decreased in the cultures treated with L-GSH [12,13,15,16], (Figure 3 and Figure 4)

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Using both reverse genetic and pharmacological approaches, we have demonstrated that TGR is an essential and druggable target for the treatment of schistosomiasis 18,19,20

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Due to Xareltos high plasma protein binding, the drug is not dialyzable, meaning dialysis cannot be used to remove the medication from the patients blood