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Negatively charged nanoparticles and hydrophilic excipients generally demonstrate reduced interaction with mucus, whereas positively charged and hydrophobic agents tend to interact more strongly

Neurosteroids that are known to be relatively potent positive modulators of GABAergic neurotransmission include ALLO, pregnanolone, and TDHOC

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However, we understood that the experimental condition using in vitro culture of tendon fibroblasts could not mimic the real environment of tendon