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Patients in this group usually have significant night pain with an inability to lie on their shoulders and restricted activities in lifting their arm above shoulder level, typical mid-arc impingement pain

At week 12 after discontinuation of AOMs, significant weight regain was observed in the GLP-1 related drug subgroup compared to the control group

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Beyond classical antioxidant signaling, GSH interfaces with additional pathways, including Hippo-Yes1 associated transcriptional regulator (YAP1) signaling to regulate GPX4 and SLC7A11 expression, 159,160 mechanistic target of rapamycin kinase (mTOR) signaling to influence GPX4 protein synthesis through cysteine metabolism, 161 and NF-B signaling to restrain inflammation-associated ROS production 162

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