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Several clinical trials examining NAC in COVID-19 have been planned NCT04545008, NCT04419025, NCT04455243, and NCT04374461

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Molecules administered by intrathecal administration still encounter barriers within the subarachnoid space for drug penetration from CSF into brain parenchyma, but IT dosing creates a favorable concentration gradient for drugs to diffuse

doi:10.1126/science.289.5484.1567