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The study, called TRIUMPH-4, didn't solely focus on weight loss, meaning that other trials specifically designed for that outcome could produce different or higher results

Low magnesium impairs cardiac muscle repolarisation, increasing the risk of premature ventricular contractions (PVCs) that patients perceive as skipped beats

For the polyglutamylation to be effective and to achieve tissue retention, 5-methyl-THF needs to be first metabolized to THF via the methionine cycle

Ethics declarations Ethics approval and informed consent The investigators in this study did not have direct access to individual patient data for this analysis

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