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Integrins v6 and v8 on fibroblasts activate TGF-1 by binding the RGD-motif on LAP and inducing a conformational change ( (381-397 a.a.) , highly abundant in the serum of OA patients, competes with TGF-1 for integrin binding and can attenuate TGF-1 activation ( The initiation of the canonical TGF- signaling pathways involves -glycan serving as a co-receptor to present TGF-1 to transmembrane serine/threonine kinase type I and type II receptors (TGFBR1 and TGFBR2, respectively) ( Figure 6 )

PMID 13374343

Figure 3 illustrates this fundamental mechanism that connects stress to the gut and from there to the psyche-brain system

1 Gastrointestinal Research Gastrointestinal investigations have examined BPC-157 across both acute and chronic injury models involving the oesophagus, stomach, small intestine and lower gastrointestinal tract

Treatment of vitamin B 12 and folate deficiencies