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Pharmacokinetics and drug metabolism GLP-1RA was developed to be resistant to the degradation of DPP-4

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In ALS, multiple lines of evidence support the involvement of this pathway: 1) GSH depletion and reduced GPX4 expression are commonly observed in ALS patients and mouse models (367, 368, 371)

Given the negative surface charge and absence of targeting ligands, our nanocarrier is unlikely to utilize receptor or adsorptive-mediated transcytosis