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Anwar is with the Department of Dermatology and Venereology, Faculty of Medicine Universitas Hasanuddin, Dr

doi: 10.1016/j.freeradbiomed.2008.05.004

The Na + /K + -ATPase dysfunction and subsequent calcium overload not only impair energy utilization but also further promote mitochondrial ROS production and mtDNA release, which may serve as DAMPs to activate downstream immune pathways, forming a metabolic-immune cross-talk at the cellular level

Vitamins can only be of assistance if dietary intake is inadequate