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Activation of the PPP has also been demonstrated in cancer cells, probably to produce more NADPH to combat oxidative stress [230]

3.2.1 Keap1-Nrf2-ARE signaling pathway activators 3.2.1.1 Epigallocatechin 3-Gallate (EGCG) EGCG, a bioactive constituent extracted from green tea, is widely investigated in various diseases, such as cardiovascular diseases, diabetes and cancer

Hereditary xanthinuria type II associated with mental delay, autism, cortical renal cysts, nephrocalcinosis, osteopenia, and hair and teeth defects

verified by radiation-induced rat model that resveratrol downregulated the inflammatory response and apoptosis through NF-B signaling pathway in rats, and alleviated the post-radiation inflammation and injury in rats

Melatonin expresses anti-inflammatory and antioxidant properties, and regulates different biological functions such as sleep, circadian rhythm, immunity, reproduction and blood pressure control