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Competitive binding assays at Y2-R Peptide binding to the human Y2-R was measured in a dose-responsive manner (1 pM1 M) using a radioligand competitive binding assay in CHO-K1 cells

Kynurenines and depression in other neurobiological conditions Alterations in KYN metabolism extend beyond MDD and have been implicated in a range of neurobiological conditions associated with depressive symptoms, such as bipolar disorder, schizophrenia, Alzheimers disease, and acquired brain injury

10.1038/npp.2014.74 Neuropsychopharmacology 4 AlhadeffA

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Similar to the transcriptomic changes observed in the hypothalamus, we found that the conjugate prompted transcriptional patterns enriched for functional terms associated with synaptic transmission, including postsynaptic specialization and neuron-to-neuron synapse in the brainstem (Extended Data Fig