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In the noncanonical pathway, Yang and the team found that LPS activation in the cytosol triggers caspase-11-dependent cleavage of the pannexin-1 channel, followed by ATP release, activating the purinergic P2X7 receptor, leading to cytotoxicity
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Biomarkers of immune activation such as NK cell activity, CD8 + T cell infiltration, cytokine profiles (IL-12, IFN- and IL10), and Treg/MDSC ratios help identify populations of patients likely to benefit from immunomodulatory agents whereas circulating levels of polyphenols, isoflavones or glucosinolate metabolites serve as a marker for PK properties that can be utilized to optimize dosing and exposure (224)
39 Therefore, a phase 3 study examining the efficacy and safety of lanifibranor in adult patients with MASH and fibrosis stages F2 and F3 (NATiV3) is currently underway (NCT04849728)
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