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Zepbound side effects & warnings As with similar drugs, the most common side effects of Zepbound are stomach-related and include: Nausea Vomiting Diarrhea or constipation Stomach pain Indigestion and heartburn Burping Other common side effects may include: Injection site reactions (redness, itching, pain, or rash near the injection site) Allergic reactions Tiredness Hair loss This is not a full list of side effects