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Furthermore, GLP-1 enhances beta-cell mass by mediating proliferation and differentiation and inhibiting apoptosis ( Glucose-dependent insulinotropic polypeptide is a 42 aa peptide, which mainly originates from enteroendocrine K cells ( Since inhibition of DPP4 due to genetic deletion or use of DPP4 inhibitors was shown to elevate GLP-1/GIP levels in numerous studies, this effect is the main focus of developing therapeutic targets for treatment of T2DM

Oral GLP 1 medications for weight management that are peptides need to be taken on an empty stomach thirty minutes before anything else

Pancreatitis Acute pancreatitis has been reported with all GLP-1 agonists, though causal relationship remains debated [19]

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