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Addressing these challenges will facilitate the progress of TCM-derived SIRT1 activators toward effective clinical application in RA treatment

It scavenges free radicals to protect the mitochondria from potential damage and dysfunction

CGA is considered one of the most important dietary phenolic compounds, exhibiting a wide range of biological activities, such as antioxidant, anti-inflammatory, anticancer, antibacterial, hepatoprotective, cardioprotective and neuroprotective effects, and modulation of lipid and glucose metabolism [3,4,5]

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