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More detailed mechanistic studies are needed to elucidate the reason for the preferential accumulation in the mitochondria

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Acta Neuropsychiatr 34:318329 Altamimi TR, Thomas PD, Darwesh AM, Fillmore N, Mahmoud MU, Zhang L, Gupta A, Al Batran R, Seubert JM, Lopaschuk GD (2018) Cytosolic carnitine acetyltransferase as a source of cytosolic acetyl-COA: a possible mechanism for regulation of cardiac energy metabolism

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There is compelling evidence from preclinical studies that l-carnitine and ALCAR can improve energy status, decrease oxidative stress and prevent subsequent cell death in models of adult, neonatal and pediatric brain injury