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When an amylin analogue like cagrilintide is paired with a GLP-1/GIP receptor agonist, the complementary mechanisms appear to produce additive appetite suppression: cagrilintide slows gastric emptying through amylin receptor activation, while tirzepatide simultaneously boosts insulin secretion and reduces glucagon

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doi: 10.1016/j.clinthera.2017.05.354 79 LeonNLaCoursiereRYaroshDPatelRS

Gallbladder problems: Ozempic may increase the risk of gallbladder problems, such as gallstones