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195 NPL4ubiquitin fusion degradation 1 (UFD1) heterodimers interact with the p97/VCP N domain and capture ERAD substrates via their Lys48-linked polyubiquitin signature

[DOI] [PMC free article] [PubMed] [Google Scholar] 510.Gromada J., Bokvist K., Ding W.G., Holst J.J., Nielsen J.H., Rorsman P

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Our functional and structural data suggest that receptor conformational dynamics associated with flexibility of the peptide N-terminal activation domain may be a key determinant of agonist efficacy