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Vitamin B12 is important for breaking down fatty acids and amino acids

The overexpression of USP10 significantly increases the expressions of SIRT6, Nrf2, and HO-1 in LPS-treated HK-2 cells, effectively reducing the shedding and local vacuolar degeneration of RTECs, the number of inflammatory cells, and improving renal function

[1] [6] Severe deficiencies may include symptoms of reduced heart function, suppression of bone marrow, as well as more various severe neurological symptoms possibly including sensory loss, abnormal balance and reflexes, memory and consciousness impairment, smell and taste problems, depression, irritability, confusion, and psychosis

These mechanisms include impaired axonal transport (Collard et al., 1995

PMID 41610736