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How does retatrutide differ from semaglutide and tirzepatide?+ Semaglutide targets GLP-1 alone and tirzepatide targets GLP-1 and GIP

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In obese mice, FNDC5/irisin improves insulin resistance, corrects glucose and lipid metabolic abnormalities, and enhances lipolysis via the cAMP-PKA-HSL/perilipin pathway (Xiong et al., 2015)