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Elevated IGF-1 beyond the upper physiological range raises concerns about downstream effects, including fluid retention, carpal tunnel syndrome, and theoretical long-term risks requiring further evaluation

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In our GBM models, depletion of the cellular NADH pool resulting from the combined treatment of sertraline and chloroquine might enhance the sensitivity of resistant GBM cells to chloroquine by increasing the availability of the NADH-binding pocket to exert its function