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To assess the functional relevance of ASPL in ULK-mediated phosphorylation of VCP, we next performed live-cell imaging assays using G3BP-tdTomato knock-in U2OS cells stably expressing WT GFP-ASPL or D351A GFP-ASPL and either WT VCP or a phosphomimetic VCP mutant in which all three ULK-dependent phosphorylation sites (serine-13, serine-282, and threonine-761) were mutated to aspartates (3SD)

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Obesity, smoking, chronic pancreatitis, and longstanding diabetes independently increase pancreatic cancer risk

Normal beta-hCG levels at 5 weeks are approximately 200 to 10,000 mIU/mL in twins and can be considerably overlapped by singleton pregnancies, which can make diagnosis difficult

Experimental chelation therapy in chromium, lead, and boron intoxication with N-acetylcysteine and other compounds