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Notably, MST traces indicated that interactions between truncated Syn variants and Syn WT did not result in spontaneous aggregation

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El-Shehawi et al., 2021), as well as gene-defiant mice such as those considered leptin resistance ( db/db ) (Tang et al., 2017) are known to progressively develop T2D, including its complications involving oxidative stress and inflammation

This subsequently contributes to the pathophysiological progression of type 2 diabetes, obesity-related metabolic syndrome, and microvascular complications (diabetic nephropathy, retinopathy)