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[2] The primary role of GSTs is to catalyze the conjugation of glutathione (GSH) with the electrophilic centers of a wide variety of molecules

The twice-daily preparation has historically shown higher nausea rates of up to 30-40% of patients, while the extended-release formulation demonstrates improved tolerability

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Therefore, GHK-Cu does not have FDA GRAS status for oral dietary supplement use

Clinicians and patients are reminded to be alert to initial symptoms such as severe, persistent stomach pain that may radiate to the back and may be accompanied by nausea and vomiting, said the MHRA, adding that patients who experience this should be advised to seek urgent medical attention