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The efficacy of systemic GLP-1R agonists to attenuate cocaine seeking is associated with increased activity of GABA neurons in the VTA While an emerging literature indicates that activation of VTA GLP-1Rs is sufficient to reduce drug-seeking behavior 8,14 , the cell type-specific neural mechanisms underlying the efficacy of GLP-1R agonists and increased GLP-1 signaling in the VTA on cocaine seeking remain largely unknown

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