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Manufacturer guidelines are intentionally conservative to ensure maximum effectiveness

Synergy happens when the combined effect of two medications is greater than the sum of their individual effects

Plans may provide a temporary period to regain eligibility, but the rules and length of that period vary

as a continuous variable), female gender (1.48), Asian (1.25) or African origin (1.29), diabetes (1.27), obesity (1.31), hypothyroidism (1.38), chronic liver (1.24) or kidney disease (1.25), alcohol consumption (1.22), exercise (1.23), the use of antiarrhythmic agents (1.31), calcium channel blockers (1.36) or statins, primarily at high doses (1.38) [411]