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Measurable density changes are typically not visible to the naked eye yet

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At 3 months, the Nu+Ex group showed significant improvements in gait speed, 5 sit-to-stand performance, SPPB scores, depressive symptoms, perceived health, fat-free mass, and appendicular muscle mass

Considering all these data together, it is reasonable to assume the existence of an RBC-Hb self-assembly system and a spontaneous system of drug release by RBCs after oral or intravenous administration of this drug, which provided a new understanding of the discrepancy between the high tissue concentration and extremely low plasma concentration of berberine