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NAC has been previously shown to rescue DPI-induced cell death ( 2.8 In vivo evaluation of MitoQ and DPI: tolerability and limited efficacy in NB mouse models Finally, to evaluate the efficacy of MitoQ and DPI in vivo , both drugs were administered individually and in combination to Th- MYCN transgenic NB mice

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But if the deficiency is caused by an irreversible inability to absorb the vitamin, a lifelong treatment with pharmacological doses of B12 is needed

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