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GLSs have at least three isoforms, GLS1, GLS2, and GAC (a splicing isoform of GLS1), all of which were recently reported to be localized in mitochondria 18,19,20

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Significantly, enhanced transamination and aspartate synthesis in K-Ras-driven cancer cells are important in the promotion of nucleotide biosynthesis 184 and maintenance of redox balance 29

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Experimental models investigating this peptide combination often measure parameters such as angiogenic marker expression, fibroblast migration, extracellular matrix remodeling, and connective tissue organization

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