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Central nervous system involvement is further supported by GLP-1 production in caudal brainstem neurons, key integrators of vagus nerve-mediated gut-brain signaling 53,54,55,56

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The STEP-5 trial found that gastrointestinal side effects were most common early on but usually short-lived

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Inositol, akin to a B vitamin, aids in the distribution of fat and in maintaining a healthy cell structure, while Choline supports liver function and fat excretion

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