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Specifically, TSA alleviates the inhibition of cyclin kinase inhibitors p27 by cut-like homeobox 1 (Cux1) and groucho-related gene 4 (Grg4) and increases the expression of p27 by inhibiting the elevated expressions of HDAC1 and HDAC3 in the kidneys of Pkd1-deficient mice to inhibit cell proliferation in the nephrogenic zone, ultimately reducing cysts in neonatal Pkd1-deficient mice (Livingston et al., 2019)