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5.3'INHIBITION'OF'GLUTATHIONE'SYNTHESIS'IN'MURINE'MELANOMA'CELLS'72' 6.'DISCUSSION'75' 6.1.'TARGETING'ANTIOXIDANTS'IN'CANCER'75' 6.2'FERROPTOSIS'IN'CANCER'76' 6.3'GLUTATHIONE-DEPENDENT'INDUCTION'OF'A'PHENOTYPIC'SWITCH'IN'MELANOMA'79' 6.4'NRF2'INDUCTION'AND'AGGRESSIVENESS'IN'MELANOMA'81' 6.5'EFFECTS'OF'GLUTATHIONE'DEPLETION'ON'REPROGRAMMING'AND'ENHANCED'TUMOR'GROWTH'82' 7.'CONCLUSION'84' 8.'APPENDIX'85' 8.1'BRAF'INHIBITOR-RESISTANT'MELANOMA'CELLS'85' 8.2'INVESTIGATION'OF'CTH'INHIBITION'IN'VIVO'87' 9.'BIBLIOGRAPHY'92' 10.'ACKNOWLEDGEMENTS'104' 11.'CURRICULUM'VITAE'105' 1!!!!Summary

Under hypoxic conditions, pyruvate is converted into lactate during glycolysis [20]

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Insight into the Effects of High-Altitude Hypoxic Exposure on Learning and Memory