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Clinical studies have demonstrated that GLP-1 receptor agonists can reduce various inflammatory biomarkers , including: C-reactive protein (CRP) : A general marker of systemic inflammation Interleukin-6 (IL-6) : A pro-inflammatory cytokine Tumour necrosis factor-alpha (TNF-) : Another key inflammatory mediator Plasminogen activator inhibitor-1 (PAI-1) : Associated with cardiovascular inflammation The magnitude of these effects varies between studies and may depend on baseline inflammatory status, degree of weight loss achieved, and individual patient characteristics

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The glucagon-like peptide 1 analog liraglutide reduces TNF--induced oxidative stress and inflammation in endothelial cells

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Because the TCA cycle and the electron-transporter channel require NAD + and NADH, respectively, an optimal NAD/NADH ratio is needed for efficient mitochondrial metabolism