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Dectin-1 activation by particulate - glucans was shown to promote the production of pro-inflammatory cytokines IL-6, IL-8, and TNF- in THP-1 macrophages via co-binding with TLR2 and TLR4 (184), as also shown in Figure 4

However, 59 participants regained weight, with a mean regain of 16.07 13.87 lbs (range 270 lbs), while 19 participants had no net weight change

Subsequent research revealed its potential sleep-inducing properties

Most information comes from animal studies (where doses are scaled by body weight) and anecdotal reports from users