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10.1042/bsr20090138 126 MaryT

Melanocortins in research: complete guide to Melanotan II, PT-141 bremelanotide, afamelanotide and MC1R-MC5R receptors The melanocortin system is a central and peripheral neuroendocrine network formed by five G protein-coupled receptors (MC1R through MC5R), their endogenous ligands derived from proopiomelanocortin (POMC) alpha-MSH, beta-MSH, gamma-MSH, ACTH and their natural antagonists agouti (ASIP) and AgRP