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Acknowledgements The authors are grateful for the support received from the Austrian Science Fund (FWF, P 29379-B28), the Tyrolean Science Fund (TWF, 0404/1812), the Austrian Society of Gastroenterology and Hepatology (GGH) and the European Crohns and Colitis Organisation (ECCO) (to T.E.A.)

Pandolfi, Pro-senescence therapy for cancer treatment

DSIP has a plasma half-life of only a few minutes due to rapid degradation by blood peptidasesyet behavioral effects in sleep normalization and HPA axis modulation persist for days to weeks after a single administration

In a controlled human trial, GHK-Cu applied to skin raised collagen in 70% of volunteers, beating vitamin C (50%) and retinoic acid (40%), and improved firmness and elasticity

As such, the mechanism underpinning the induction of eryptosis by heavy metals is of considerable interest, and it is under investigation in various studies