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Moreover, over the course of evolution, SQOR function has specialized in different species: in the nematode Caenorhabditis elegans , SQOR family members have diverged such that SQRD-1 serves as the primary H 2 S detoxification enzyme (able to use either ubiquinone or rhodoquinone as electron acceptor), whereas SQRD-2 acts as a negative regulator that accelerates recovery from H 2 S exposure (Romanelli-Cedrez et al., 2024)

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