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Results showed that combination treatment with lower dose of metformin (0.1 mmol/L) and liraglutide (3 nmol/L) eliminated the inhibitory effects of PA (0.5 mmol/L) on the protein levels of GLP-1R (marginally) and p-PKA (completely)

The metabolic benefits appear to result from multiple mechanisms, including enhanced mitochondrial function, improved insulin signaling, and activation of metabolic regulatory pathways controlled by sirtuins

However, in erythrocytes, GSH levels after SAG administration were slightly lower than those observed with the GSH product, suggesting a complex regulation of GSH and its oxidized form (GSSG) within erythrocytes

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