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Finally, a retrospective cohort study compared 1775 matched pairs of SGLT2i users and nonusers with SLE and type 2 diabetes from the TriNetX database and found that use of SGLT2i was associated with significantly reduced risk of lupus nephritis, dialysis, kidney transplant, heart failure, and all-cause mortality compared with no SGLT2i use 8 9,10

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To approach the efficacy of BS, dual and triple agonists combining GLP-1 with other entero-pancreatic hormones with complementary actions, including glucose-dependent insulinotropic polypeptide (GIP), glucagon (GCG) and amylin are currently under development [15]