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Furthermore, although we endeavored to include studies that performed stratified analyses of patients with schizophrenia, the interpretability and generalizability of the results may still be constrained by limited sample sizes and considerable population heterogeneitysuch as confounding factors including age, gender, ethnicity, smoking history, and BMI ( 7 Conclusions and discussion 7.1 Integrated mechanisms of the microbiota-gut-brain-immune axis in schizophrenia By integrating the evidence discussed throughout this review, we propose a comprehensive model illustrating the MGB-immune interactions in schizophrenia (See Figure 3 )

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Thus, in situ produced microbial folate may favourably influence the cellular nutrition of the local colonocytes and may be important in maintaining intestinal homeostasis and modulating gut microbiome function, e.g., through regulation of colon mucosal proliferation (i.e., colorectal cancer prevention) and its anti-inflammatory effects 248,249,256,257,277,278,279,280,281,282,283,284,285,286