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Collectively, our data reveal that Y37P substitution in Cagri (from Amy) promotes differential engagement of the Cagri peptide with each RAMP that contributes to distinct conformational dynamics from those observed for each individual rAmy-bound AMYR complex

Motor : muscle weakness, ataxia, reduced reflexes (if peripheral neuropathy) or increased reflexes and/or upgoing plantars (if central neuropathy)

Puncturing the BAC water stopper, invert the vial, and inject the air from the syringe into the vial

Randomised, double-blind, placebo-controlled parallel group study of P54FP for the treatment of dogs with osteoarthritis

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