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Can be used as monotherapy or in combination with other diabetes medications including metformin, sulfonylureas, SGLT2 inhibitors, and insulin

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The best understood effectors for this process are PDE3B and ABHD15 that operated by the suppression of cAMP to attenuate pro-lipolytic PKA signaling toward adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), and perilipin (PLIN)

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