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The increase in the proportion of Firmicutes / Bacteroidetes exacerbates liver inflammation and immune disorders, while the decrease in the abundance of Saccharomyces cerevisiae leads to the accumulation of the gut microbial metabolite 1-phenyl-1,2-propanedione, which participates in APAP-induced ALI by depleting hepatic glutathione levels (82)

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Both companies run aggressive capital-spending programs totaling more than USD 20 billion between 2024 and 2026 to double semaglutide and tirzepatide output