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It seems that the efficacy of B9 supplementation is dose-dependent such that, the combination of 1 mg/d folic acid, 25 mg/d vitamin B6, and 400 g/d B12 during 6 months did not have any significant effect on serum homocysteine and symptoms of migraine (74)

In individuals homozygous for the C677T polymorphism in the MTHFR gene, low riboflavin status is associated with elevated plasma homocysteine, and in turn linked with a higher risk of cardiovascular disease and other chronic diseases (13, 14)

P., Wilding, J

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